heartbroken alluring: October 2012

Wednesday, October 31, 2012

The Hot Wheels Camaro: no longer just a toy

By Paul A. Eisenstein, TheDetroitBureau.com

Chevrolet and Mattel have had a long and prosperous relationship. The toy company has been producing matchbox-sized replicas of the Camaro since 1968, a year after the real Chevy pony car first landed in showrooms.

At the upcoming SEMA auto show in Las Vegas, the automaker plans to return the favor, introducing the first production version of the?Chevrolet Camaro to bear a Hot Wheels badge.

TheDetroitBureau: Iconic London 'black' cab could soon vanish

Chevy has used the Hot?Wheels theme for several years at its SEMA stand. Last year, it positioned a bright yellow version of the Camaro at the base of a life-size track.? But now the automaker plans to actually add a Hot Wheels edition to its lineup.? It will come as a $6,995 upgrade on both the 2013 Chevrolet Camaro and Camaro convertible. Sales are scheduled to begin early next year.

For the money, the special edition will get a bright metallic paint scheme, special graphics, red-lined 21-inch wheels and Hot Wheels flame badges on the fenders and trunk lid.

TheDetroitBureau: Nation?s fastest highway opens

The Hot Wheels Camaro will feature matte-black touches around the hood and taillight surrounds. And the upgrade will also borrow some trim pieces from the high-performance Camaro ZL1 package, including the rear spoiler, front grille and front splitter.

The black leather-trimmed interior will boast Hot Wheels logos embroidered on the front seats, which are finished in red and black stitching.? The Hot Wheels flame will adorn the door interiors with special Hot Wheels Edition sill plates completing the package.

Chevrolet?s MyLink infotainment package will come standard.

TheDetroitBureau: Chevy moving up-market with Sonic Dusk

The Hot Wheels Camaro can be ordered with either the Chevy 2LT package with its 3.6-liter V-6, rated at its stock 323 horsepower, or the 400-hp 2SS package featuring the 6.2-liter L99 V-8.? The 2SS will be delivered with a dual-mode exhaust system, as will the 2LT equipped with a manual gearbox.

Chevy can only hope to match the success of the 1:64 edition Camaros that Mattel has sold by the millions over the last 44 years. The pony car was one of 16 original Hot Wheels models ? a favor being returned as the Chevrolet Hot Wheels Camaro becomes the first production car to carry the toy series? name.

The DetroitBureau: Honda designs car exclusively for women

The project was launched in 2010 and initially was focused on the concept model unveiled at the SEMA show last year. The final production design for the 2013 street car was taken from one of five sketches worked up by Hot Wheels chief designer Felix Holst.

?It?s been nearly 20 years since I started designing?cars for Hot Wheels and I have yet to drive one home,? said Holst, the vice president of creative for the Mattel Wheels Division. ?Personally, I can?t wait to open the doors and see the Hot Wheels Camaro sitting in the garage.?

Source: http://bottomline.nbcnews.com/_news/2012/10/30/14781558-the-hot-wheels-camaro-no-longer-just-a-toy?lite

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Monday, October 29, 2012

Gigantic Hurricane Sandy bears down East Coast

NEW YORK CITY (Reuters) - Tens of millions of people along the U.S. East Coast girded themselves on Sunday for Hurricane Sandy, a gigantic storm forecast to assault the densely populated region with battering winds, dangerous flooding and even heavy snowfall.

Sandy, expected to come ashore late on Monday, could deliver a harsh blow to major cities in its target zone including New York, Philadelphia, Washington, Baltimore and Boston. Its center was forecast to strike New York-New Jersey area and then move inland toward Philadelphia and the rest of Pennsylvania.

The sheer size of the storm meant its effects would be felt from the mid-Atlantic states to New England. Officials warned of widespread power outages that could last for days.

In New York City, subway, bus and train service will be suspended on Sunday evening and up to 375,000 people were ordered to evacuate from low-lying areas.

President Barack Obama, speaking after a briefing at the federal government's storm response center in Washington, called Sandy a "serious and big storm" and asked residents to heed the orders of state and local authorities to protect themselves from its onslaught.

"It's a very, very large system," National Hurricane Center Director Rick Knabb said. "The storm is going to carve a pretty large swath of bad weather, both water and wind."

The storm could bring the country's financial nerve center to a standstill, although the major Wall Street exchanges said they planned to open as usual on Monday because they have alternative facilities they can use.

Worried residents in the hurricane's path packed stores, searching for generators, flashlights, batteries, food and other supplies in anticipation of power outages.

New York City schools will be shut on Monday. Other local governments also announced school closures.

Gale-force winds were already starting to buffet Virginia and could reach other parts of the mid-Atlantic coast on Sunday night. Tens of millions of people will feel its bluster for as long as two days, Knabb said.

Forecasters said Sandy was a rare, hybrid "super storm" created by an Arctic jet stream wrapping itself around a tropical storm, possibly causing up to 12 inches of rain in some areas, as well as up to 2 feet of snowfall in the Appalachian Mountains from West Virginia to Kentucky.

It could be the largest storm to hit the United States, according to the National Oceanic and Atmospheric Administration's (NOAA) website.

Sandy was already disrupting transportation systems. More than 700 flights, including international ones, were canceled on Sunday and nearly 2,500 more were canceled for Monday, FlightAware.com said.

CASINOS CLOSE

New Jersey casinos were ordered to close and state officials decided to shut bus and rail systems by early on Monday.

Governors in other states put National Guard troops on alert. "We're just asking people to be patient and be ready for a long haul. But we have a very aggressive power restoration program in place and I think we're ready," Virginia Governor Robert McDonnell told the CNN program "State of the Union."

In Washington, Obama said officials had assured him that they had all the resources they needed in place, and he stressed that "it is important for us to respond big and to respond fast" to the hurricane's onslaught.

"We're going to cut through red tape and we're not going to get bogged down in a lot of rules," said Obama, who was having to juggle both is re-election bid and his efforts to stay on top of the storm's impact just nine days before Election Day.

Sandy blew the presidential race off course, forcing Obama and Republican challenger Mitt Romney to cancel scheduled campaign stops. It fueled fears that the storm could disrupt early voting ahead of the November 6 election.

INSURERS PREPARE FOR STORM

U.S. stock exchanges and Wall Street banks were sending employees into Manhattan on Sunday to stay in hotels and co-workers' homes, as markets prepared to open for business on Monday even as Sandy brought public transportation to a halt.

Insurers also prepared for the storm's arrival, activating claims teams, staging adjusters near the locations most likely to be affected and generally getting ready to pay for a potentially huge volume of losses.

While Sandy's 75 mph winds were not overwhelming for a hurricane, its exceptional width means the winds will last as long as two days, wearing down trees, roofs and buildings and piling up rainfall and storm surge.

Hurricane-force winds extended 175 miles from the center of the asymmetrical storm, while its lesser tropical storm-force winds spanned 850 miles in diameter.

"That's gigantic," said Chris Landsea, the hurricane center's science and operations officer.

At high tide, it could bring a surge of seawater up to 11 feet above ground level to Long Island Sound and New York Harbor, forecasters said.

"Given the large wind field associated with Sandy, elevated water levels could span multiple tide cycles, resulting in repeated and extended periods of coastal and bayside flooding," the forecasters said.

Sandy was centered about 250 miles southeast of Cape Hatteras, North Carolina, or 575 miles south of New York City at midday on Sunday, the hurricane center said. It pushed seawater up over the barrier islands off North Carolina known as the Outer Banks.

"It's flooded all over the village," longtime Ocracoke Island resident Kathleen O'Neal told Reuters. "I would say between a foot and two feet of water."

Sandy was moving over the Atlantic parallel to the U.S. coast at 10 mph, but was forecast to make a tight westward turn toward the U.S. coast on Sunday night.

Sandy killed at least 66 people as it made its way through the Caribbean islands, including 51 in Haiti, mostly from flash flooding and mudslides, according to authorities.

(Additional reporting by Gene Cherry in North Carolina, Dave Warner in Philadelphia, Paul Thomasch in New York, Mary Ellen Clark and Ebong Udoma in Connecticut and Will Dunham in Washington; Writing by Jane Sutton and David Adams; Editing by Will Dunham)

Source: http://news.yahoo.com/threat-hurricane-sandy-grows-targets-east-coast-020222965.html

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Friday, October 26, 2012

Video: Dunham films Obama campaign ad about her 'first time'...voting

Sandy bringing floods, winds, snow -- but where?

The entire Northeast coast was told Friday to be prepared for potential flooding, high winds and even snow early next week as Hurricane Sandy made its way north after killing 41 people in the Caribbean.

Source: http://www.msnbc.msn.com/id/3036697/vp/49574264#49574264

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TELUS offers up estimated release times for Jelly Bean updates

Jelly Bean

With Android 4.1 Jelly Bean updates around the globe, Samsung reminded U.S. Galaxy S3 owners their update was still coming but neglected to say when exactly. Couple that information with the estimated times TELUS has now posted for the Canadian Jelly Bean schedule and it's not a far stretch to think the U.S. variants will arrive around the same time or sooner for some carriers:

Samsung Galaxy S II x - 4.1 - OEM not yet submitted - Late December
Samsung Galaxy Note - 4.1 - OEM not yet submitted - Late December
Samsung Galaxy S III - 4.1- OEM not yet submitted - Late November

Even though they are just estimates, it's nice to see them laid out and not really that far off. In that past, TELUS has done fairly well with letting everyone know when their updates are coming, so we'll see how close they are this time around.

Source: TELUS via: Mobile Syrup

Source: http://feedproxy.google.com/~r/androidcentral/~3/aNpnHCtuXKo/story01.htm

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New genomics study shows ancestry could help solve disease riddles

ScienceDaily (Oct. 25, 2012) ? Explosive advancement in human genome sequencing opens new possibilities for identifying the genetic roots of certain diseases and finding cures. However, so many variations among individual genomes exist that identifying mutations responsible for a specific disease has in many cases proven an insurmountable challenge. But now a new study by scientists at The Scripps Research Institute (TSRI), Scripps Health, and Scripps Translational Science Institute (STSI) reveals that by comparing the genomes of diseased patients with the genomes of people with sufficiently similar ancestries could dramatically simplify searches for harmful mutations, opening new treatment possibilities.

The work, reported recently in the journal Frontiers in Genetics: Applied Genetic Epidemiology, should speed the search for the causes of many diseases and provide critical guidance to the genomics field for maximizing the potential benefits of growing genome databases.

Much work is already under way to sequence the DNA of people suffering from diseases with unknown causes, called idiopathic conditions, to find the roots of their problems. Unlike more complex conditions such as diabetes, in some cases a limited number of genetic defects, or even a single mutation, can cause an idiopathic disease. Identifying those critical mutations can lead to effective treatments for previously mysterious problems.

Complicated Searches

While there have been some successes, in many other instances the genetic basis of an idiopathic disease remains elusive. Among other groups, The National Human Genome Research Institute runs searches for idiopathic disease sufferers and is able to find offending gene sequences only about 30 percent of the time. "One explanation for that other 70 percent might be that the diseases are enormously complex," said the new study's senior author Nicholas Schork, a professor at TSRI, director of research for Scripps Health's genomic medicine program, and director of biostatistics and bioinformatics at STSI, "but it could be that they're still searching in the noise."

The new work offers a likely filter for much of that noise. The results show that comparing a person's DNA sequence against existing genomes for those whose ancestry is not sufficiently similar, as is typically the case, can cause serious problems. Countless differences that seem unique to a patient might instead be DNA variants carried by everyone with the same ancestry. A researcher might, for instance, identify hundreds of variants and not be able to zero in on the one responsible for a disease.

But the new results show that comparing closer ancestry matches will dramatically reduce the number of variants identified as potentially responsible for a disease, reducing a search to a workable number.

For the work, the team developed a tool called the Scripps Genome Adviser. This processing framework uses a supercomputer to incorporate a variety of databases and algorithms to identify DNA variants in a particular genome relative to reference genomes. It then uses algorithms to analyze these variants and predict whether they have any physiological effects, and if so what those might be.

The team began with nearly 60 whole human genome databases and ran three key types of computing experiments. First the researchers identified the number of variants in the reference human genomes and found that on average each has millions of variants, about 12,000 of which have functional effects. Then the scientists looked at the rates at which variants appeared in various ancestry lines.

Honoring Ancestry

Importantly, the scientists didn't stop there. They deliberately inserted a mutation known to cause disease into a genome, then ran this genome through the Adviser to see how effectively it could identify that known variant as unique.

When the team ran the searches comparing that altered genome against a reference panel of genomes that included different ancestries, the known variant remained effectively lost in a sea of other variants. But comparison against genomes of similar ancestry dramatically reduced the number of variants identified, allowing identification of the inserted disease-causing gene.

A study published simultaneously with the Scripps team's paper by Professor Carlos Bustamante and colleagues from Stanford University also pointed to ancestry's importance, but this is the first time a team has been able to look at the problem on the whole-genome scale. "Others have indeed recognized ancestry as important," said Schork, "but no one had shown how much it could haunt a particular study, especially on a whole genome basis."

As importantly, prior to this study it wasn't clear how to address the ancestry issue. But the new study provides clear direction. The team calculated that identification of the vast majority of ancestral variants can be performed successfully with a reference panel of less than 20 genomes -- though it could well take more to identify a particular ancestry group's rarest deviations. Of course, most people have more than one ancestry line, meaning that in practice a patient's reference panel would need to include multiple reference groups.

This result should act as a guide for continuing genomics work. Many ancestries are already well represented, meaning that assembling an effective reference panel is possible in some cases. But the number of whole genomes from a particular ancestral group isn't the only consideration. Ideally, reference genomes need to be from relatively disease-free people, meaning subjects who lived to an old age without major complications from genetic conditions.

Recognizing the importance of ancestral comparisons, researchers and companies can now deliberately work to fill any holes. "Building those sorts of resources could only benefit the community," said Schork. In fact, Schork, Ali Torkamani and others at Scripps are collaborating with Complete Genomics, Inc., a whole genome sequencing company in Mountain View, CA, to develop appropriate reference panels for clinicians and researchers.

Deciphering Diseases

Schork and his colleagues are already working toward broader application of their results using an increasingly advanced version of the tool. While processing a single person's genome to identify and analyze variants took about four days when the project began, today the Adviser can accomplish the task in about 30 minutes.

Along with the paper's lead author Torkamani, Schork is a founder of a company called Cypher Genomics that has licensed the Scripps Genome Adviser for disease-focused research. The teams in both industry and academia hope not only to continue idiopathic disease research, but also to apply similar principles to search for the causes of more complex congenital conditions. "The broader message of our work is that you have to take ancestry into account no matter what disease you're studying," said Schork.

This research was supported by the National Institutes of Health (grant numbers 5 UL1 RR025774, 5 U01 DA024417, 5 R01 HL089655, 5 R01 DA030976, 5 R01 AG035020, 1 R01 MH093500, 2 U19 AI063603, 2 U19 AG023122, 5 P01 AG027734, 1 U01 HG006476-01), the Stand Up to Cancer Foundation, the Price Foundation and Scripps Genomic Medicine.

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Story Source:

The above story is reprinted from materials provided by The Scripps Research Institute.

Note: Materials may be edited for content and length. For further information, please contact the source cited above.

Journal Reference:

Ali Torkamani, Phillip Pham, Ondrej Libiger, Vikas Bansal, Guangfa Zhang, Ashley A. Scott-Van Zeeland, Ryan Tewhey, Eric J. Topol and Nicholas Schork. Clinical Implications of Human Population Differences in Genome-wide Rates of Functional Genotypes. Front. Gene., 2012 DOI: 10.3389/fgene.2012.00211

Note: If no author is given, the source is cited instead.

Disclaimer: This article is not intended to provide medical advice, diagnosis or treatment. Views expressed here do not necessarily reflect those of ScienceDaily or its staff.

Source: http://feeds.sciencedaily.com/~r/sciencedaily/top_news/top_health/~3/Xeg5uqPNIPQ/121025152748.htm

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Thursday, October 25, 2012

stock market news: Sure Fire Badminton Drills, Sports & Recreation

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Source: http://institutionalization-forfeiture.blogspot.com/2012/10/stock-market-news-sure-fire-badminton.html

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U.S. death toll rises to 24 in meningitis outbreak

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Source: http://news.yahoo.com/u-death-toll-rises-24-meningitis-outbreak-042716569.htmlwest virginia university michele bachmann tim howard west virginia rob roy gaslight justin timberlake

Justin Timberlake & Jessica Biel's Wedding Photo Revealed

People Exclusive

By Jennifer Garcia

10/24/2012 at 07:50 AM EDT

Justin Timberlake and Jessica Biel

Judging by their wedding photo, Justin Timberlake was more than ready to jump into his new life with Jessica Biel, springing airborne with joy.

When the couple of five years exchanged personal vows in a romantic Italian ceremony Oct. 19, "it was a really special evening," Timberlake, 31, tells PEOPLE in this week's cover story, in which the newlyweds open up for the first time about their special day and share exclusive photos.

"It was a total fantasy experience," adds Biel, 30.

One cause for emotion? The singer-actor played the guitar and serenaded his beautiful bride-to-be as she walked down the aisle in a custom, petal pink Giambattista Valli Haute Couture gown.

"It was an original piece I wrote specifically for the evening and for her," says Timberlake, who wore a Tom Ford tux he helped design.

The pair welcomed 100 guests, including close friends Jimmy Fallon, Andy Samberg, Timbaland and Biel's 7th Heaven costar Beverley Mitchell, to the Borgo Egnazia resort in southern Italy for a week-long wedding celebration.

"It was a lot to ask of them to travel, so we figured we'd give our guests a good party!" says Timberlake.

For Justin and Jessica's exclusive wedding album ? from the bride's special "something borrowed" to the couple's dance moves ? pick up this week's issue of PEOPLE, on newsstands Friday

Source: http://feeds.people.com/~r/people/headlines/~3/fconFS3rHYw/0,,20641685,00.html

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Jamie Dupree's Washington Insider: New Obama and Romney ads out

By Jamie Dupree

Both the Obama and Romney campaigns rolled out new television ads in the immediate aftermath of the final Presidential debate in Boca Raton, Florida, with just two weeks until Election Day.

The new Obama ad is targeted at key swing states like Florida and Ohio, and is basically a summary of very familiar arguments by the President on why he should be re-elected.

"We've made real progress," the President says into the camera, "and the last thing we should do is turn back now," arguing that voting in the Republicans will take the country back to the Bush years.

As for the Romney ad, this one comes from last night's debate, and focuses on the "Apology Tour" as Romney derisively labeled the President's trip to the Middle East, where Mr. Obama visited a series of Arab nations, but not Israel.

Expect a lot of ads over the next two weeks as the pace gets a bit more frantic in the race for the White House.

About Jamie Dupree

Jamie Dupree is the Radio News Director of the Washington Bureau of the Cox Media Group and writes the Washington Insider blog.

Connect with Jamie Dupree on:TwitterFacebook

Send Jamie Dupree an email.

Source: http://www.krmg.com/weblogs/jamie-dupree/2012/oct/23/new-obama-and-romney-ads-out/

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Pulitzer prize board adds New Yorker writer, playwright and newspaper editor

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